• Faculty Work
Hudson, E.,♦ Faylinn, C.,♦ Lopez-Miranda, I.R., Milstein, J.N.*, and Beharry, A.A.* (2024)

Antimicrobial efficacy of photocaged β-lapachone in Bacillus subtilis biofilms. ChemPhotoChem (Accepted)

♦ Co-first authors, * Co-corresponding authors

Campbell, J.W., Tung, M.T., Taylor, B.B., Beharry, A.A., and Thompson, A. (2024)

A series of potent BODIPY photosensitisers featuring tellurophene motifs at boron. Org. Biomol. Chem., 2024, 22, 4157-4162.

Ayan, S., Rotaru, A.M., Kaye, E.G., Juneau, G., Das, S., Wilds, C.J., and Beharry, A.A. (2024)

A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase. Org. Biomol. Chem., 2024, 22, 2749-2753. 

Kailass, K., Casalena, D., Jenane, L., McEdwards, G., Auld, D.S., Sadovski, O., Kaye, E.G., Hudson, E., Nettleton, D., Currie, M.A., and Beharry, A.A. (2024)

Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation. J. Med. Chem., 2024, 67, 3, 2019-2030

Campbell, J.W., Tung, M.T., Robertson, K.N., Beharry, A.A, and Thompson, A. (2023)

BODIPYs with Chalcogenophenes at Boron: Synthesis and Properties. J. Org. Chem., 2023, 88, 15, 10655-10661.

Kaye, E.G., Mirabi, B., Lopez-Miranda, I.R., Dissanayake, K.C., Banerjee, U., Austin, M., Lautens, M., Winter, A.H., and Beharry, A.A. (2023)
Digby, E.M., Ayan, S., Shrestha, P., Gehrmann, E.J., Winter, A.H., and Beharry, A.A.* (2022)

Photocaged DNA-Binding Photosensitizer Enables Photocontrol of Nuclear Entry for Dual-Targeted Photodynamic Therapy. J. Med. Chem., 2022, 65, 24, 16679-16694.

Ozsan, C., Kailass, K., Digby, E.M., Almammadov, T., Beharry, A.A., Kolemen, S. (2022) Selective detection of carboxylesterase 2 activity in cancer cells using an activity based chemiluminescent probe. Chem. Commun., 2022, 58, 10929-10932. 
Kailass, K., Sadovski, O., Zipfel, W.R. and Beharry, A.A. (2022) Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence. J. Med. Chem., 2022, 65 (13), 8855-8868 
Digby, E.M., Tung, M.T., Kagalwala, H.N., Ryan, L.S., Lippert, A.R. and Beharry, A.A. (2022) Dark Dynamic Therapy: Photosensitization without Light Excitation Using Chemiluminescence Resonance Energy Transfer in a Dioxetane–Erythrosin B ConjugateACS Chem. Biol., 2022, 17 (5), 1082-1091 
Campbell, J.W.,♦ Tung, M.T.,♦ Diaz-Rodriguez, R.M., Robertson, K.N., Beharry, A.A*, and Thompson, A*. (2021)

Introducing the Tellurophene-Appended BODIPY: PDT Agent with Mass Cytometry Tracking Capabilities. ACS Med. Chem. Lett. 12(12), 1925-1931

♦ Co-first authors, * Co-corresponding authors

Digby, E.M., Ma, T., Zipfel, W.R., Milstein, J.N. and Beharry, A.A. (2021) Highly Potent Photoinactivation of Bacteria Using a Water-Soluble, Cell-Permeable, DNA-Binding Photosensitizer. ACS Infect. Dis., 7(11), 3052-3061
Kaye, E.G., Kailass, K., Sadovski, O. and Beharry, A.A. (2021) A Green-Absorbing, Red-Fluorescent Phenalenone-Based Photosensitizer as a Theranostic Agent for Photodynamic Therapy. ACS Med. Chem. Lett.,12(8), 1295-1301
Digby, E.M., Sadovski, O. and Beharry, A.A. (2020) An Activatable Photosensitizer Targeting Human NAD(P)H: Quinone Oxidoreductase 1Chem. Eur. J., 26, 2713 -2718
Kailass, K., Sadovski, O., Capello, M., Kang, Y., Fleming, J.B., Hanash, S.M. and Beharry, A.A. (2019) Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensorChem.Sci., 10, 8428-8437.
Digby, E.M., Rana, R., Nitz, M. and Beharry, A.A. (2019) DNA directed damage using a brominated DAPI derivativeChem.Commun., 55(67), 9971-9974.
Gharibi, N., Kailass, K. and Beharry, A.A. (2019) Exploiting the Cellular Redox-Control System for Activatable Photodynamic Therapy. Chembiochem., 20(3), 345-349. 
Singh, K., Rotaru, A.M., and Beharry, A.A. (2018) Fluorescent Chemosensors as Future Tools for Cancer Biology. ACS Chem. Biol., 13(7), 1785-1798. 
Beharry, A.A. (2018) Next-Generation Photodynamic Therapy: New Probes for Cancer Imaging and Treatment. Biochemistry, 57(2), 173-174. 
  • Postdoctoral Work
Nagel, Z.D., Beharry, A.A., Mazzucato, P., Kitange, G.J., Sarkaria, J.N., Kool, E.T., and Samson, L.D. (2019) Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells. PLoS ONE. 14(2): e0208341
Wilson, D.L., Beharry, A.A., Srivastava, A., O'Connor, T.R. and Kool, E.T. (2018) Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses, Angew. Chem. Int. Ed. , 57(39), 12896-12900.
Tahara Y.K., Auld D., Ji D., Beharry, A.A., Kietrys A.M., Wilson D.L., Jimenez M., King D., Nguyen Z., and Kool E.T. (2018)

Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. J. Am. Chem. Soc., 140(6), 2105-2114. 

Ji, D., Beharry, A.A., Ford, J.M. and Kool, E.T. (2016)

A Chimeric ATP-linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target. J. Am. Chem. Soc., 138(29), 9005-9008. 

Beharry, A.A., Nagel, Z.D., Samson, L.D. and Kool, E.T. (2016)

Fluorogenic Real-time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor drug Response. PLoS ONE, 11(4), e0152684.

Beharry, A.A., Lacoste S., O’Connor T.R. and Kool, E.T. (2016)

Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation by ALKBH3, a Prostate Cancer Marker. J. Am. Chem. Soc., 138 (11), 3647–3650.

  • Ph.D. Work
Dong, M., Babalhavaeji, A., Samanta, S., Beharry, A.A., and Woolley, G.A. (2015)

Red-shifting azobenzene photoswitches for in vivo use. Acc. Chem. Res., 48 (10), 2662-2670

Samanta, S.†, Beharry, A.A.†, Sadovski, O., McCormick, T., Tropepe, V. and Woolley, G.A. (2013)

Photo-switching azo compounds in vivo with red light. J. Am. Chem. Soc., 35 (26), 9777–9784.
Equal contribution. Article highlighted in Nature Chemical Biology.

Beharry, A.A., Chen, T., Al-Abdul-Wahid, M.S., Samanta, S., Davidov, K., Sadovski, O., Ali, A.M., Chen, S.B., Prosser, R.S., Chan, H., and Woolley, G.A. (2012) Quantitative analysis of the effects of photoswitchable distance constraints on the structure of a globular protein. Biochemistry, 51, 6421-6431.
Rullo, A., Beharry, A.A., Gomez-Biagi, R.F., Zhao, X., and Nitz, M. (2012)

Site-selective affinity labelling of maltose binding protein in bacterial cells. ChemBioChem. 13(6), 783-787.

Beharry, A.A., Sadovski, O., and Woolley, G.A. (2011)

Azobenzene Photo-switching without Ultraviolet Light, J. Am. Chem. Soc., 133(49), 19684-19687.

Beharry, A.A., and Woolley, G.A. (2011)

Azobenzene Photoswitches for Biomolecules, Chem. Soc. Rev., 40(8), 4422-4437. Highly cited paper by Thomson Reuters, Web of Science.

Lee, A., Dubinsky, S., Tumarkin, E., Moulin, M., Beharry, A.A., and Kumacheva, E. (2010)

Multifunctional Hybrid Porous Polymer-based Materials, Adv. Funct. Mater., 21, 1959–1969

Beharry, A.A., Wong, L., Tropepe, V., and Woolley, G.A. (2010)

Fluorescence imaging of azobenzene photoswitching in vivo, Angew. Chem. Int. Ed., 50, 1325-1327. Article highlighted as a “Hot Paper”.

Sadovski, O., Beharry, A.A., Zhang, F., and Woolley, G.A. (2009)

Spectral tuning of azobenzene photo-switches for biological applications, Angew. Chem. Int. Ed., 48, 1484-1486.

Beharry, A.A., Sadovski, O., and Woolley, G.A. (2008)

Photo-control of peptide conformation on the timescale of seconds with a conformationally constrained, blue -absorbing, photo-switchable linker. Org. Biomol. Chem., 6, 4323-4332. Article highlighted as a “Hot Paper”.

Beharry, A.A., and Woolley, G.A. (2011)

"Photoswitch design" book chapter in Photosensitive control of biological function, Humana Press, Editor: James Chambers and Richard Kramer, p. 171-184.

Beharry, A.A., and Woolley, G.A. (2010)

"Photoswitches" book chapter in Laser imaging and manipulation in cell biology, Wiley-VCH Verlag GmbH, Editor: Francesco S. Pavone, p. 83-97.